January 27, 2012

#TwoBits - Scare Tactics, Altered Images and Diabetes Ads

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Riva Greenburg has a wonderful piece  (first of two pieces) up on the Huffington Post about Agriculture and Health. I found fascinating the idea of linking farm policy and health. I thought the idea that incentives for health based agricultural goal vs demonizing was a fascinating way of approaching the issues. It’s kinda like the idea of positive emotional behavior as motivation vs scare tactics and shame to get individuals to deal with the diet health and relationship in their individual lives. 


Speaking of scare tactics, there is an ad running by NYC that shown an amputee than links diabetes, soda and amputations. In an interesting twist to the scary ad in question - it is photoshopped. Boston.com reports that photo is digitally altered and not of an amputee or even diabetic. The poll in the Boston.com piece is running in favor of the altered ad. Apparently photoshopping images to make models skinny on magazine covers is bad but faking amputations is OK. 


What is your view of digital manipulation to make a point? How about scare tactics - think they work? 
Sysy has a piece up on The Girls’d Guid to Diabetes about scare tactics and this adRiva also has some great words about the campaign in her back issues. 

January 16, 2012

The Brits Crack Me Up.

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#TwoBits A Great #DSMA Live Replay and #TuDiabetes Live

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Here’s a quick #TwoBits* around the DOC this week.
Replay the DSMA Live show from week guest Lane Desborough.  Lane shares his career, passion & glimpse inside of his life as a Parent of a child w/ diabetes. In addition to being a T1D Dad Lane is a key part of the Medtronic brain trust helping shape T1D care. I have met the guy and listening to him is a great investment of time.  http://dsmalive.com/2012/01/13/after-thoughts-lane-desborough/
Friday January 20, Join the TuDiabetes for a live video chat with C.C. King, Ph.D., Associate Research Scientist at the UC, San Diego Pediatric Diabetes Research Center. Dr. King will begin by presenting a brief overview of his research into stem cell therapy for type 1 diabetes, followed by a live Question & Answer session with the TuDiabetes community!
Time:
* 1/20/12 1 pm Pacific Standard Time (GMT -8)
* 1/20/12 4 pm Eastern Standard Time (GMT -5)
*If you see an interesting pair of posts around the Diabetes Online Community (DOC) how about sharing them with the rest of us with the hash tag #TwoBits in case others missed them?

January 14, 2012

Stem Cell Reports and Asking questions.

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There are a number of headlines about stem cells as a cure for type 1 that have been written in the past few days. They are based on a study out of China the reports to have reeducated lymphocytes aka T cells. I read this article and am left with far more questions than I am comfortable with. Josh Levy has a sound write up, I recommend his write up
In part here why I have questions. In other news this week identified CD8 T cells as the source of the autoimmune response that causes type 1.1 There is a quote from ViaCyte on Diabetes Mine that spoke  to the difficulty of  getting stem cells to differentiate into beta cells.2 For that I presume that getting a stem cell to differentiate into any specific cell is an involved proposition. 
The lymphocytes reportedly reprogramed in the China study are already differentiated cells.  If the autoimmune process is stopped it is due to a modification or reeducation of these CD8 T cells. There are a myriad of CD8 cells and they are created in the lymph nodes to recognize specific antigens on the cells the are programmed to kill. 

Differentiated means a stem cell became a specific cell in the body. That is they started off as a stem cell and became a specific type of t cell. Very loosely hematopoietic stem cel in bone marrow become a common lymphoid projenitor that becomes a T cell.
This study suggests that exposure to stem cells changes the existing antigen receptors. If that is true then why don’t the stem cell that become to the lymphocytes in our bone marrow have the same effect? I also fail to see a mechanism to explain how this erase the memory of the adaptive immune system. Why is it the type 1 autoimmune T cells that are reeducated and not say the one that provide immunity to chickenpox.  
All that said I would love to see a cure. I get excited by headlines just like everyone else. I hope this is repeatable. I have come to be suspicious of reports of apparatus that seem to good to be true. 

I would hope that the news agencies that report this kind of study know enough to ask some basic questions. Among them should be how does it work, is it peer reviewed and has the study been repeated? 
1 La Jolla Institute researchers identify pivotal immune cell in Type 1 diabetes in humans, http://www.eurekalert.org/pub_releases/2012-01/ljif-lji011112.php
2 http://www.diabetesmine.com/2012/01/whats-up-with-diabetes-stem-cell-research-firm-viacyte.html

January 13, 2012

#TwoBits on Cure Research. One Guy: Joshua Levy

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Here’s a quick #TwoBits* from around the DOC.
We of us living with T1D want a cure. A lot of us also want an easy way to keep track of progress towards cure. My Go To Guy is Joshua Levy. In late December he wrote two essays well worth reading for those looking for cures. 
http://cureresearch4type1diabetes.blogspot.com/2011/12/two-essays-on-progress.html
Of Mice and Men: Joshua also started a new blog. One dedicated to all the NOD Mice that get cured. The freaking mice get cured all the time and each time starts a cycle of a cure is coming headlines. It is nice then to have a resource that knows the difference between curing mice and people while still keeping an informed eye on what is going one with the rodents. 
http://t1dcuredinmice.blogspot.com


*If you see an interesting pair of posts around the Diabetes Online Community (DOC) how about sharing them with the rest of us with the hash tag #TwoBits in case others missed them?

January 12, 2012

#TwoBits Diabetes Sisters & Stem Cells at the Mine.

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Here’s a quick #TwoBits* from around the DOC.
1: Registration for Diabetes Sisters annual conference open January 1st. I hear they are already about half way booked. For more information see: http://www.diabetessisters.org/events/nationalconference
2: Diabetes Mine has an interesting piece on encapsulated stem cells research. An outstanding read. http://www.diabetesmine.com/2012/01/whats-up-with-diabetes-stem-cell-research-firm-viacyte.html
*If you see an interesting pair of posts around the Diabetes Online Community (DOC) how about sharing them with the rest of us with the hash tag #TwoBits in case others missed them?

January 11, 2012

Of Fantasy Diabetes Devices, Sheldon & Dewy

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Victoria’s Secrets holiday runway special has past, football is winding down so maybe we need some new fantasy league to talk about. How about insulin pumps? 
I had a fascinating conversation with Greg from Medtronic at CWD’s Friends For Life last summer on the topic of what would be my fantasy pump. A plausible device, that is one based on current technology, insulins etc.. I would say that a full artificial pancreas is beyond that scope but only a little. 
Yes it takes a particular lack of a real life to have fascinating conversations about fantasy pumps. You can call me Sheldon if you must. It turns out for me the fantasy isn’t a pump, and so the talk expanded out to a fantasy diabetes management system. Greg asked if I thought FDA would approve my fantasy devices. I allowed as how they  probably wouldn’t but industry would probably wouldn't make it either.
Meet DEWY, he's a winner. 
I think the tools to available to manage diabetes are fairly good. I think there is a significant opportunity for better diabetes care through breaking down the technological towers of Babble that separate devices from each other and our lives. My fantasy device would be a common collection point for diabetes information in a way that would facilitate managing lives with diabetes not just adjusting parts of those lives. 
Our meters, pumps, CGMs need to talk together and work through a common Diabetes User Interface. A D.U.I. 
WAIT! We can’t call it D.U.I.! That’s been used. 
How about DEWY for ah.. um.. er.. Diabetes Equipment Works for You.   
Dewy’s job is to listen for information from devices and lives. Then to integrate that into a possible responses. Dewy should work for us, patients, in our lives. Dewy should try to accommodate our individual life styles not define them. 
Dewy should help out with the basics. If we are low or high Dewy needs the wizard logic already in pumps to help calculate corrections or carbs based on our particular insulin and carb sensitivity. Dewy should have access to food databases with the ability to create a meal list in a way that approaches the ease of use of making play lists in iTunes. Drop and drag foods into a meal, easily adjust quantities of food in a meal, calculate carbs and even make note of fat, fiber and protein. Parents will want to be able to store these 'cause kids eat the same meal over and over again, by choice. Dewy should be able to help adjust boluses based on all of that but like any good friend of a diabetic not be too pushy about it. 
Dewy could even help out tracking trends. He could gently mention times of the day that he sees spikes. He could pay attention to our post workout BGs and see if there are trends worthy of note. Along the same lines Dewy could even try to pay attention to two hour post meal BGs and make suggestions about I:C rates. He could look for between bolus times when basals are responsible for what happening with BG and point out trends. 
Dewy would scream bloody murder if he ever sees serious overnight lows. He would turn off basals and wake up everyone and anyone we say with phone calls and text messages and keep at it until we tell him it is OK. That is just the kinda guy Dewy is.
Some folks like patch pumps, some traditional pumps and some folks like shots. To accommodate those life styles choices Dewy should be independent of device manufacturers. That is Dewy should be able to accommodate what ever meter, pump or cgm an individual chooses. Dewy should be smart and tag along with us patients wher  we do our living so he will need to reside on the smart phone of our choice. 
Dewy isn’t an artificial pancreas, not that he wouldn't be willing to work with one. An AP tries to be a pancreas. AP wouldn't care what you ate or if you worked out. Dewy being a really good diabetes assistant would, if we wanted him to, track what we eat or how our workouts impact our lives. 
Dewy would talk wirelessly to devices; pumps, meters, CGMs. He would do this securely and let us know if he is in touch or lost connection to devices. He would be the universal remote to the show that is our diabetes lives. When we change to a device that woks better in our life, Dewy could cope. He would have simple friendly ways to enter shots, exercise, and daily, weekly and monthly cycles. He would let us invent variables of our own because, well, our diabetes many vary. 
Until there are artificial pancreases, smart insulins, encapsulated implantable functioning beta cells and the cure that reverses the autoimmune glitch that causes type 1 diabetes families will need to manage diabetes. Managing diabetes will requires multiple devices to measure and adjust blood glucose but wouldn’t be cool if they all played nice? 
Well that’s my crazed fantasy pump. This got me wondering what others would see as a fantasy diabetes device? What is yours?

Accu-Chek Nano FDA Approved.

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Roche announced that they have FDA approval for the NANO in the US.
Innovative, small, no code device will be available to people with diabetes in the U.S. in first half of 2012
Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that it has received clearance from the U.S. Food and Drug Administration (FDA) for its Accu-Chek® Nano SmartView blood glucose monitoring system. The new Accu-Chek Nano meter, which is smaller than a standard credit card, employs a large brilliant backlit display and does not require any manual coding or code key for enhanced ease of use. It also offers improved functions such as customizable test reminders, pre- and postmeal markers and average glucose calculation. The Accu-Chek Nano meter uses Accu-Chek® SmartView test strips and will be available to customers in the first half of 2012. 
Our pals across the pond did a review of the Nano a while back: http://www.shootuporputup.co.uk/2009/06/review-roche-accu-chek-aviva-nano/